The prohibit will require effect from October 1 after MPs chosen to alter what the law states.
Plans were submit to "safeguard youthful individuals from the intense health harms of smoked tobacco".
In Parliament, 342 MPs chosen in favour in comparison to simply 74 against.
Campaigners stated it had been one step forward but stated more must be done.
Chief Medical Officer Professor Dame Sally Davies stated: "The passing of rules to create smoking in cars transporting under 18s illegal is really a significant victory for safeguarding children's health from second-hands smoke.
"Smoking only a single cigarette inside a vehicle exposes children to high amounts of air contaminants and cancer-leading to chemicals like arsenic, chemicals and tar."
Dr Cent Forest, leader from the British Lung Foundation, known as it a "tremendous victory for that 500, 000 children being uncovered to second-hands smoke in the household vehicle each week in England".
She known as for standardised packaging for those tobacco items, inside a bid to chop the amount of children taking up smoking.
About 200, 000 children occupy smoking each year within the United kingdom.
The charitable organisation formerly stated it believed that 430Thousand youngsters are uncovered to second-hands smoke within their family vehicle each week.
The prohibit may come as an appointment continues to be happening on plans to prohibit under-18s from purchasing electric cigarettes.
But Simon Clark, director from the smokers' group Forest, stated: "Legislation is excessive. The overwhelming most of people who smoke know it's inconsiderate to smoke inside a vehicle with children present plus they do not do it. They do not require the condition micro-controlling their lives."